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NEW YORK (Reuters Health) - Young adults who abuse amphetamines may be raising their risk of suffering a heart attack, a new study shows.

Texas researchers found that among more than 3 million 18- to 44-year- olds hospitalized in their state between 2000 and 2003, those who were abusing amphetamines were 61 percent more likely than non-users to be treated for a heart attack.

What’s more, the rate of amphetamine-linked heart attacks rose by 166 percent over the 4-year study period. That compared with a 4-percent rise in cocaine-related heart attacks, the researchers report in the journal Drug and Alcohol Dependence.

"Most people aren’t surprised that methamphetamines and amphetamines are bad for your health," lead researcher Dr. Arthur Westover said in a statement.

"But we are concerned because heart attacks in the young are rare and can be very debilitating or deadly," added Westover, an assistant professor of psychiatry at the University of Texas Southwestern Medical Center at Dallas.

Amphetamines stimulate the central nervous system and some are used to treat attention-deficit hyperactivity disorder, or ADHD. But they are also frequently used illegally; one potent form of amphetamine, methamphetamine, is a growing problem in many U.S. cities.

Cases of heart attack in young people have been linked to amphetamine abuse before, but the current study appears to be the first large- scale look at the epidemiology of the problem.

Westover and his colleagues used a statewide database to examine information on more than 3.1 million 18- to 44-year-olds discharged from Texas hospitals between 2000 and 2003. Overall, 11,011 of these patients (0.35 percent) were treated for a heart attack.

The database also contained information on whether a patient had been diagnosed with any type of drug-abuse problem. The researchers found that patients with a diagnosis of amphetamine abuse or dependence were at increased risk of suffering a heart attack.

Amphetamines have various effects that could precipitate a heart attack, Westover and his colleagues point out. The drugs are well known to speed up heart rate and blood pressure, but they can also trigger spasms in the heart arteries and promote blood clotting.

In people who already have "plaque" deposits in their heart arteries, amphetamines may cause a plaque to rupture, which can then lead to a heart attack.

Besides the risk to individual amphetamine users, Westover said, "we’re also concerned that the number of amphetamine-related heart attacks could be increasing."

"We’d rather raise the warning flag now than later," he added. "Hopefully, we can decrease the number of people who suffer heart attacks as the result of amphetamine abuse."

WASHINGTON (AP) — Sure, exercise is good for your waistline, your heart, your bones — but might it also help prevent addiction to drugs or alcohol?

There are some tantalizing clues that physical activity might spur changes in the brain to do just that.

Now the government is beginning a push for hard research to prove it.

This is not about getting average people to achieve the so-called runner’s high, a feat of pretty intense athletics.

Instead, the question is just how regular physical activity of varying intensity — dancing, bicycling, swimming, tae kwan do — might affect mood, academic performance, even the very reward systems in the brain that can get hijacked by substance abuse.

What first caught the attention of National Institute on Drug Abuse chief Dr. Nora Volkow: A study found tweens and teens who reported exercising daily were half as likely to smoke as their sedentary counterparts, and 40 percent less likely to experiment with marijuana.

Volkow knows — from her own 6-mile daily runs and from her scientific experiments — that the brain literally likes physical activity. Exercise seems to invigorate neurochemicals that sense and reinforce pleasure.

"In children, it’s innate," she notes. "Children want to move."

But the nation’s children are becoming more sedentary, as illustrated by the obesity epidemic, "screen time" replacing outdoor play and a drop in school P.E. And as youngsters approach adolescence, the run around the yard that used to be fun too often becomes a chore — the dreaded jog around the school track or the nagging to get off the couch. The sedentary teen turns into the sedentary adult.

"Why do we lose the ability to experience pleasure from physical activity?" asks Volkow.

Last week she brought more than 100 specialists in exercise and neurobiology to a two-day conference to explore physical activity’s potential in fighting substance abuse, and announced $4 million in new research grants to help.

Drug treatment programs often include exercise, partly to keep people distracted from their cravings, but there’s been little formal research on the effects.

The best evidence: Brown University took smokers to the gym three times a week and found adding the exercise to a smoking-cessation program doubled women’s chances of successfully kicking the habit. The quitters who worked out got an extra benefit: They gained half as much weight as women who managed to quit without exercising, says lead researcher Dr. Bess Marcus.

She now is working with the YMCA on a larger, NIDA-funded study to prove the benefit.

Marcus cautions that people trying to kick an addiction have a powerful incentive to exercise. Could that possibly translate into prevention? Among the clues:

– Rats were less likely to ingest amphetamines if their cages had running wheels, suggesting exercise stimulated a reward pathway in the brain to leave them less vulnerable to the drug’s rush.

– In people, exercise acts as a mild antidepressant and relieves stress. Depression, anxiety and stress increase risk of alcoholism, smoking or drug abuse.

– Volkow is intrigued that attention deficit disorder and obesity both involve problems with the brain chemical dopamine, one system that drugs hijack to create addiction.

– Baby monkeys who don’t play enough in childhood have problems controlling aggression when they’re older. The most aggressive tend to have defects involving the feel-good brain chemical serotonin — and binge-drink when researchers offer them alcohol.

– Back to rats, physical activity increases production of growth factors and stem cells in key brain regions important for learning and mood; increases formation of blood vessels; and strengthens communication networks between brain cells.

Together, that’s far too little research to know if exercise really matters for substance abuse, scientists at the National Institutes of Health meeting cautioned.

But, a few studies of school-age children suggest physical activity predicts better performance on math, verbal and other tests — and better school performance in turn is linked to lower risk for substance abuse.

And getting sedentary seniors moving improves brain function — research aimed at preventing dementia, not drug abuse, although the improvement is in an area that in younger people is linked to risky decision-making.

A caveat: If your own youth includes memories of parties with beer-guzzling athletes, well, the research concurs. A major study that tracks adolescent risk behaviors found that by 12th grade, exercise offers no protection against binge-drinking.

"Now the kids who exercise the most actually drink the most," says Dr. Lloyd Johnston of the University of Michigan. It may have to do with the celebratory nature of team sports, or getting revved for college — or, other researchers suggested, even that competition is to blame.

OMAHA, Nebraska (AP) — Only an anti-anxiety medication turned up in toxicology tests done on the body of the 19-year-old gunman who fatally wounded eight people before killing himself last month at a shopping mall.

 The autopsy report on Robert Hawkins revealed diazepam in his system. The tranquilizer is better known by its market name, Valium. Douglas County Attorney Don Kleine told the Omaha World-Herald in a copyright story Tuesday that authorities sometimes "see people who have abused drugs or alcohol to give them the ability to carry out their misdeed."

"In this case, it doesn’t appear he had abused either," he said.

The teen’s blood revealed only therapeutic levels of the medication.

The autopsy report also said Hawkins killed himself December 5 by a single shot from his assault rifle from under his chin.

Before committing suicide, Hawkins went into the Von Maur store at Westroads Mall and took an elevator up to the third floor. There he opened fire, fatally wounding eight people. Five other people were hit by bullets or bullet fragments, injuring two seriously.
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Investigators will try to find out whether Hawkins had a prescription for the Valium, he needed Valium Detox, Kleine said.  Diazepam is often given to people who have anxiety attacks or insomnia, said Dr. Todd Stull, director of the University of Nebraska Medical Center’s drug and alcohol program.

"It’s a calming kind of medicine," Stull said. "A lower dose can help with anxiety."

People can get high on it, he said, but "it’s not a very common addiction."

Court records and friends say Hawkins regularly smoked marijuana, but Kleine said there was no evidence of it or any other drugs in his blood.

Brad Renfro, the former child star whose later career was hampered by drug and alcohol problems, has been found dead at his Los Angeles home. He was 25.According to reports, Renfro’s body was discovered at 9am yesterday. The cause of death has yet to be determined, although the actor is believed to have been out drinking with friends the night before his death. "He was working hard on his sobriety," Renfro’s lawyer Richard Kaplan said yesterday. "He was doing well. He was a nice person."

Raised by his grandmother in Knoxville, Tennessee, Renfro was plucked from obscurity at the age of 12 to star alongside Susan Sarandon and Tommy Lee Jones in the 1994 blockbuster The Client, based on the bestseller by John Grisham. The following year he won the Hollywood Reporter’s "young star" award. Renfro went on to enjoy a fitfully successful acting career with a starring role in Bryan Singer’s Apt Pupil and supporting turns in the likes of Sleepers, Bully and Ghost World. He recently completed work on the Bret Easton Ellis adaptation The Informers, in which he stars alongside Winona Ryder and Tommy Lee Jones. But Renfro’s career was often overshadowed by his off-screen trials. In May 2006 he served 10 days in jail after attempting to buy heroin from an undercover police officer in LA’s Skid Row area. More recently, Renfro claimed he was making efforts to stay clean. "I’m tired of paying the consequences," he said.