Summer House

ORLANDO, Fla. — When Bryan stopped taking drugs six months ago, he got through the worst of his heroin withdrawal in a week. It was Xanax that tortured him for a full month.

He longed for the "benzos," slang for benzodiazepines, the class of drugs that includes Xanax, to take the edge off his skittishness, sleeplessness and anxiety.

Although Bryan used a variety of drugs for about 12 years, the Orlando man found Xanax one of the hardest to let go.

"Once you get fixated on downers like that, you don’t stop easily," said Bryan, 29, who asked not to be identified by last name to protect his business. "Especially if you’re a high-strung individual, it just gives you an extremely relaxing feeling. It’s slows down your thought process; you take everything in stride."

Xanax is a prescription medication used to treat anxiety. But it also is a highly abused, easily addictive tranquilizer and the focus of a fraudulent prescription drug charge against Gov. Jeb Bush’s 24-year-old daughter, Noelle.

If convicted, officials said, Noelle Bush likely would be given probation as a first-time offender.

She will not be required to appear in court personally until after formal criminal charges are filed, a process that generally takes four to six weeks, Leon County Assistant State Attorney Owen McCaul said.

Xanax and other prescription drugs are becoming increasingly popular with younger people, according to the National Institute on Drug Abuse. A government survey in 2000 found that about 5 million Americans have abused Xanax or a similar anti-anxiety drug at some point.

" It ’s basically the modern-day version of a Quaalude,  the mother’s little helper," said Lui Delgado, a certified addictions professional and executive director of Quest Counseling Centre in Altamonte Springs. " It ’s very common with young people, and it ’s very easy to find."

Xanax is the brand name for alprazolam, a drug developed at least 20 years ago as an alternative to Valium, a widely prescribed sedative that was considered too easily addictive.

But both drugs can create powerful addictions, and some say Xanax is worse than Valium.

"Xanax, in particular, is abused because it has a fairly quick uptake into the system, and many people get a buzz from it, " said Dr. Herndon Harding, medical director of Florida Hospital ’s Center for Behavioral Health.

Xanax works by depressing the central nervous system, enhancing the effects of a chemical in the brain that slows down the firing of neurons and reduces brain activity.

Bryan said taking Xanax felt like having a few drinks, minus the dizziness. He could get 100 pills for about $200, but the drug sells for up to $5 a pill on the street.

Most prescriptions call for no more than 2 mg of Xanax total a day. Because he had built up a tolerance, Bryan needed about 10 mg to get the desired effect.

The body’s reaction to the removal of a substance it has become dependent on is called withdrawal. Withdrawal causes craving for more of the substance being removed. The period of time when the body is trying to overcome its addiction is called detoxifica-tion (detox). Detox is the first step in overcoming a substance addiction such as drugs or alcohol. Detox is a pertinent step for the patient is to be successfully rehabilitated.
 

Opiate drugs such as heroin and methadone, and prescription medications including Hydrocodone, Oxycontin, Xanax, Vicodin and Lortab, require medical detox supervision. There are however, other illegal drugs such as marijuana, crystal methamphetamine, and cocaine that do not require medical detox. Since there is psychological dependence associated with these drugs, it would be wise to complete a period of stabilization. The process of drug detox requires the patient to be closely monitored by keeping vital signs, giving support and administering medications if needed. There are numerous withdrawal symptoms or side effects when a patient stops or dramatically reduces drugs after heavy or prolonged use. Those side effects include: sweating, shaking, headaches, drug cravings, nausea, vomiting, abdominal cramps, diarrhea, sleeplessness, confusion, agitation, depression, anxiety, and other behavioral changes.
There are two commonly used drugs to enable the patient to feel relief from these symptoms. First, Klonepin, which reduces physical symptoms, and Buprenophex, which is an anticonvulsant. These drugs must also be monitored as cessation produces withdrawal symptoms. Generally, the time period for drug detox is three to seven days under medically monitored supervision.
 

Alcohol detox, like drug detox, is usually accomplished in an inpatient medical facility. Duncan Raistrick identifies the key to a successful, planned detoxification is preparation. Raistrick goes further to detail that the first job of therapy is to bring the patient to a point of readiness to change their drinking behavior. Second, patients need to be given accurate information about what to expect during detoxification.
 

There are two withdrawal categories: minor, meaning early withdrawal and major, meaning late. The severity of withdrawal depends greatly on the duration of alcohol used. Alcohol Withdrawal Syndrome (AWS) falls into three main categories: central nervous system (CNS) excitation, excessive function of the autonomic nervous system (ANS), and cognitive dysfunction.5 Richard Saitz, M.D., M.P.H., states, since alcohol enhances gamma-aminobutyric acid’s (GABA) inhibitory effects on signal-receiving neurons, neuronal activity is lowered. This lowering leads to an increase in excitatory glutamate receptors. Tolerance occurs as GABA receptors become less responsive to neurotransmitters, which in turn requires more alcohol to produce the same inhibitory effect. During detox, the GABA is ineffective and unable to suppress the excitatory glutamate receptors. Detox is intended to relieve physical symptoms such as: shaking or tremors, headaches, vomiting, sweating, restlessness, loss of appetite, sleeplessness, Delirium Tremens (DT’s), hyperactivity, and convulsions. Alcohol detox medications are similar to drug detox medications: Buprenophex, certain benzodiazepines and anticonvulsant medications. Alcohol detox completion can take from three to fourteen days.
 

Norman S. Miller notes that medical management of alcohol and drug withdrawal during detoxification often is not sufficient to produce sustained abstinence from recurrent use. Therefore, further addiction treatments are needed to prevent relapse to alcohol and drug use following treatment of withdrawal.
 

In conclusion, drug and alcohol detoxification can effectively prepare the addicted abuser for rehabilitation and treatment.
 

Some physicians believe the withdrawal phase is related closely to the drug addiction - the worse the withdrawal, the more likely the continued use of the chemical to prevent withdrawal. Several factors are key to successful detoxification.
 

1. Acknowledge that there is a problem and decide to do something about it.
2. Get rid of all the drugs and paraphernalia.
3. Drop friends and associates that are tied to our drug problem.
4. Seek and accept spousal support, or support from friends, or relatives.
5. Prepare for symptoms with the support of a professional.
6. If tranquilizer drugs are needed for a few days or longer, they must be handled sensitively, as one addiction can easily replace another.

Xanax is a Central Nervous System (CNA) depressant known as benzodiazepine, which is commonly prescribed by physicians to treat panic attacks, nervousness, and tension. Xanax, also known as alprazolam, is considered to be a Schedule IV controlled substance under the Controlled Substance Act (CSA). Xanax has been used as a tranquilizer since the 1960s. With strong opposition to the use of benzodiazepines in the 1970s, there was a 25 percent drop in the number of prescriptions written and today, with approximately 3 million Americans (1.6% of the adult population) having used benzodiazepine on a daily basis for at least 12 months, they are the most controversial of all psychotropic medicines.

According to the United States Department of Justice Drug Enforcement Agency (DEA) and under the CSA, all controlled substances are rated on a five-schedule system. Schedule V, the lowest, for the potential for abuse and dependency and I, the highest. Xanax is a Schedule IV. All Schedule IV controlled substances have the following attributes: a low potential for abuse, a currently accepted medical use in treatment in the United States, and if abused, may lead to limited physical dependence or psychological dependence. Other examples of drugs included in schedule IV are Darvon®, Talwin®, Equanil®, Valium®, and Xanax®.

Although there are many benefits to taking Xanax and other Schedule IV drugs, many patients are becoming addicted and therefore require an intervention and drug treatment program to overcome their addictions. The patient’s body can also build up a tolerance to the drug and require larger doses if taken for long periods of time. With these increases in Xanax use come physical and psychological dependencies. Xanax is not drug to quit cold turkey. The Journal of Postgraduate Medicine stated that up to 25 percent of patients who stop taking their medication experienced withdrawal symptoms such as: nausea, vomiting, dizziness, headache, anxiety, irritability, insomnia, chills, lethargy, fatigue, moodiness, crying, dystonia, paresthesia, tremor, vivid dreams, and myalgias.

The National Institute on Drug Abuse found during a two-year treatment outcome study that 15 percent of heroin users also used benzodiazepines daily for more than one year, and 73 percent used benzodiazepines more often than weekly. Studies also indicate that from 5 percent to as many as 90 percent of methadone users are also regular users of benzodiazepines.

With this information in mind, the Xanax abuse treatment involves careful monitoring and counseling in an in-patient or outpatient treatment facility. The American Psychiatric Association’s (APA) report on benzodiazepines revealed that 11 to 15 percent of the adult population has taken a benzodiazepine one or more times during the preceding year, but only 1 to 2 percent have taken benzodiazepines daily for 12 months or longer. However, in psychiatric treatment settings and in substance-abuse populations, the prevalence of benzodiazepine use, abuse and dependence is substantially higher than that in the general population. Treatment encompasses a patient’s thought process, behavior, and helps them to cope with everyday life. Patients suffering from Xanax addiction should be tapered off gradually. There are basic outpatient plans available for discontinuation of the drug including: gradual discontinuance over a six to 12 week schedule, monitoring and helping the patient to feel in control of their dosage, and supplying a helpline when the patient needs reassurance. Other plans include inpatient treatment centers and 12-step programs such as Narcotics Anonymous, and drug treatment exchanges such as, Clonidine, propranolol, or carbamazepine. Although these substitutes can be dangerous, an inpatient setting where dosages can be physician monitored until the patient can reach a zero dose of the benzodiazepine is recommended.

In conclusion, Xanax and other benzodiazepines can be addictive drugs that are hard to discontinue however, they are also drugs of great benefit to patients who suffer from anxiety, depression, fear of open spaces (agoraphobia), premenstrual syndrome, and panic attacks. The patient and the physician should work together to regulate long-term usage, monitoring side effects, and any signs of abuse.

New York Times — From “Scarface” to “Miami Vice,”Florida’s drug problem has been portrayed as the story of a single narcotic: cocaine. But for Floridians, prescription drugs are increasingly a far more lethal habit.

An analysis of autopsies in 2007 released this week by the Florida Medical Examiners Commission found that the rate of deaths caused by prescription drugs was three times the rate of deaths caused by all illicit drugs combined.

Law enforcement officials said that the shift toward prescription-drug-abuse, which began here about eight years ago, showed no sign of letting up and that the state must do more to control it.

“You have health care providers involved, you have doctor shoppers, and then there are crimes like robbing drug shipments,” said Jeff Beasley, a drug intelligence inspector for the Florida Department of Law Enforcement, which co-sponsored the study. “There is a multitude of ways to get these drugs, and that’s what makes things complicated.”

The report’s findings track with similar studies by the federal Drug Enforcement Administration, which has found that roughly seven million Americans are abusing prescription drugs. If accurate, that would be an increase of 80 percent in six years and more than the total abusing cocaine, heroin, hallucinogens, Ecstasy and inhalants.

The Florida report analyzed 168,900 deaths statewide. Cocaine, heroin and all methamphetamines caused 989 deaths, it found, while legal opiods — strong painkillers in brand-name drugs like Vicodin and OxyContin — caused 2,328.

Drugs with benzodiazepine, mainly depressants like Valium and Xanax, led to 743 deaths. Alcohol was the most commonly occurring drug, appearing in the bodies of 4,179 of the dead and judged the cause of death of 466 — fewer than cocaine (843) but more than methamphetamine (25) and marijuana (0).

The study also found that while the number of people who died with heroin in their bodies increased 14 percent in 2007, to 110, deaths related to the opioid oxycodone increased 36 percent, to 1,253.

Florida scrutinizes drug-related deaths more closely than do other states, and so there is little basis for comparison with them.

It has also witnessed several highly publicized cases in recent years that have highlighted the problem. Only last year, an accidental prescription drug overdose killed Anna Nicole Smith in Broward County.

Still, the state has lagged in enforcement. Thirty-eight other states have approved prescription drug monitoring programs that track sales. Florida lawmakers have repeatedly considered similar legislation, but privacy concerns have kept it from passing.

As a result, federal, state and local law enforcement officials say, Florida has become a source of prescription drugs that are illegally sold across the country.

“The monitoring plan is our priority effort, but that is not enough,” William H. Janes, the Florida director of drug control, said in a statement accompanying the study. He said Florida was also looking at ways to curb illegal Internet sales and to encourage doctors and pharmacists to identify potential abusers.

Some local police departments have taken a more novel approach.

In Broward County on May 31, deputies completed a “drug takeback” in which $5 Wal-Mart, CVS or Walgreens gift cards were distributed to 150 people who cleaned out their medicine cabinets and turned in unused drugs in an effort to keep them out of young people’s hands.

“The abuse has reached epidemic proportions,” said Lisa McElhaney, a sergeant in the pharmaceutical drug diversion unit of the Broward County Sheriff’s Office. “It’s just explosive.”

Sun Sentinel — South Florida is tops in all the wrong things again, this time in prescription drug overdose deaths, with Palm Beach County leading the state in fatal methadone overdoses last year, and Broward ranking second in deaths involving the anti-anxiety drug Xanax and third in oxycodone fatalities.

No one knows why South Florida owns this tragic distinction, but one thing is clear: It proves why crackdowns on doctor shopping and unscrupulously run "pill mills" are so essential. And why they deserve an even higher ranking on the law enforcement priority list.

Drug addiction is not a victimless problem. Even if it’s not your loved one who’s hopelessly hooked, your safety may be affected because addicts often turn to crimes like burglary or robbery to feed their habit.

So combating addiction, and reducing the incidence of overdoses, is a societal, not just a personal, responsibility.

Fox News — A warning from the Colorado Springs Police Department. Detectives with Metro Vice Narcotics said more and more teens are throwing "pharm parties," or get-togethers where young adults abuse prescription drugs.

Detectives said most teens get the medications from their parents and grandparents medicine cabinets. They said from there, the prescription drugs are then taken to parties and shared with the group.

Over the past few months, police said a handful of teenagers have overdosed on the drugs. They said some of the more popular pills include Xanax, Valium, Percoset, Oxycontin, Vikatin and Adderall to name a few.

It is called "trail mix," or a bowl filled with prescription drugs free for the taking. Detectives with the Colorado Springs Police Department said "trail mix" is the new party favor at many teen get-togethers.

"Then the kids just take turns taking a pill of their choice to see if it affects them and to see if they like it or not," an undercover officer with Metro VNI said.

Detectives with VNI said they have seen youth ages 12 to 22 abuse the drugs.

"I have had reports of pills being taken from grandma and grandpas when they go visit, aunts and uncles, friends going over to another kids house and taking from that medicine cabinet," a VNI Detective said.

The most popular pills detectives said are schedule II medications, or drugs that are highly addictive.

"Cocaine and meth are schedule II, Adderall, Oxycontin and Percosit are all schedule II as well, so they have the same abuse and addiction potential," a VNI Detective said.

Police said the internet has only made things worse by spreading information.

"They did an interview with a youth who overdosed, and the way he chose what medication to take was if it said ‘do not use with alcohol,’ that meant to him it was a great drug to use," a VNI Detective said.

They said many teens think prescription drugs are safe because they are prescribed by a doctor.

"Definitely, we have seen overdoses," a VNI Detective said.

To keep your kids safe, police said treat your pills like a gun, lock them up and put them away.

Detectives with VNI said prescription drug abuse is a nationwide problem that also affects millions of adults. If you or someone you know is abusing prescription pills log onto the website below for help.